PEAQX tetrasodium hydrate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议

产品名称

NVP-AAM077 tetrasodium hydrate

产品介绍

PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的NMDA拮抗剂，其对hNMDAR 1A/2A和hNMDAR 1A/2B的IC₅₀值分别为 270 nM 和 29600 nM。

生物活性

PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally activeNMDAantagonist, withIC₅₀values of 270 nM and 29600 nM forhNMDAR 1A/2BandhNMDAR 1A/2B, respectively^[1].

IC₅₀& Target

NMDA Receptor

体外研究
(In Vitro)

PEAQX (3 μM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent^[2].

体内研究
(In Vivo)

PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration^[2].
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F_{3, 73}=4.99)^[2].
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment^[3].

Animal Model:	Timed, day 14 pregnant female Sprague-Dawley rats^[2].
Dosage:	10, 20 or 40 mg/kg.
Administration:	S.C.
Result:	Showed a sensitized locomotor response to PCP challenge on PN28-35.

Animal Model:	Timed, day 14 pregnant female Sprague-Dawley rats^[2].
Dosage:	4 mg/kg.
Administration:	I.P.
Result:	Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.

Animal Model:	11-week old C57BL/6 mice^[3].
Dosage:	10 mg/kg.
Administration:	IP.
Result:	Reversed the effect of PRE084 (F_3,78= 10.446, p<0.01).

分子量

560.15

性状

Solid

Formula

C₁₇H₁₅BrN₃Na₄O₆P

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 25.5 mg/mL(45.52 mM;Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.7852 mL	8.9262 mL	17.8524 mL
5 mM	0.3570 mL	1.7852 mL	3.5705 mL
10 mM	0.1785 mL	0.8926 mL	1.7852 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (178.52 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。