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Coluracetam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Coluracetam图片
CAS NO:135463-81-9
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
考拉西坦
MKC-231
产品介绍
Coluracetam (MKC-231) 是新型的胆碱吸收增强剂。
生物活性

Coluracetam(MKC-231) is a new choline uptake enhancer. IC50 value: Target: in vitro: MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect theAChEactivity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding [1]. in vivo: Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested [2].

分子量

341.40

性状

Solid

Formula

C19H23N3O3

CAS 号

135463-81-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 20 mg/mL(58.58 mM)

H2O : 0.4 mg/mL(1.17 mM;Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.9291 mL14.6456 mL29.2912 mL
5 mM0.5858 mL2.9291 mL5.8582 mL
10 mM0.2929 mL1.4646 mL2.9291 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。