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L-689560
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-689560图片
CAS NO:139051-78-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
L-689560 是一种有效的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂,抑制 GluN1 甘氨酸结合位点。L-689560 在广泛用作结合研究中的放射性标记配体,也用来研究 NMDA 受体在正常神经系统过程以及疾病中的作用。
生物活性

L-689560 is a potentN-methyl-D-aspartate (NMDA)receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2].

体外研究
(In Vitro)

L-689560 is a 2-carboxytetrahydroquinoline antagonist[2].

体内研究
(In Vivo)

L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]

Animal Model:Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1]
Dosage:1 mg/kg
Administration:IP
Result:Significantly reduced the neuroprotective effect of glycine after glycine receptors.
分子量

380.23

性状

Solid

Formula

C17H15Cl2N3O3

CAS 号

139051-78-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month