DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitivenon-NMDA glutamate receptorantagonist (IC₅₀s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)^[1].

Non-NMDA Receptor^[1]

DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons^[2].

DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex^[3].

300.14

C₈H₆N₄Na₂O₆

1312992-24-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.