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FFN511
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FFN511图片
CAS NO:1004548-96-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
FFN511 是一种靶向神经元囊泡单胺转运体 2 (VMA T2) 的荧光假神经递质 (FFNs)。FFN511 可抑制 5-羟色胺与含VMA T2的膜结合,其IC50值为 1 μM。FFN511 能直接反映细胞外渗过程中的释放动态,可用于标记活体皮质-纹状体急性切片中的多巴胺能神经末梢。
生物活性

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targetsneuronal vesicularmonoamine transporter2 (VMA T2). FFN511 inhibits serotonin binding toVMA T2-containing membranes with anIC50of 1 μM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].

体外研究
(In Vitro)

FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine[1].

Cell Viability Assay[1]

Cell Line:mouse chromaffin cells
Concentration:350 nM
Incubation Time:30 min
Result:Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient.
分子量

284.35

Formula

C17H20N2O2

CAS 号

1004548-96-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.