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Phenylpyropene C
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenylpyropene C图片
CAS NO:419532-92-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
S14-95
产品介绍
Phenylpyropene C (S14-95) 是一种JAK/STAT通路抑制剂,可以抑制 IFN-γ 介导的报告基因表达 (IC50=5.4~10.8 μM)。Phenylpyropene C 也是酰基辅酶 A 的抑制剂,IC50值为 16.0 μM。
生物活性

Phenylpyropene C (S14-95), aJAK/STATpathway inhibitor, can inhibitIFN-γmediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor ofacyl-CoA, with anIC50of 16.0 μM[1][2].

IC50& Target[1]

ACAT

16.0 μM (IC50)

体外研究
(In Vitro)

Phenylpyropene C (0.1-1000 μM) inhibits ACAT activity with the IC50of 16.0 μM in a dose dependent fashion[1].
Phenylpyropene C inhibits the IFN-γ mediated expression of the reporter gene with IC50s of 5.4 μM to approximately 10.8 μM[2].
Phenylpyropene C inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 10.8 μM in LPS/IFN-γ stimulated J774 mouse macrophages[2].
Phenylpyropene C inhibits the activation of the p38 MAP kinase, which is involved in the inducible expression of many proinflammatory genes[2].

分子量

450.57

Formula

C28H34O5

CAS 号

419532-92-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.