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ZSET-845
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZSET-845图片
CAS NO:324077-62-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ZSET-845是一种认知增强剂,可增强大鼠海马胆碱乙酰转移酶 (choline acetyltransferase) 活性。
生物活性

ZSET-845 is a cognitive enhancer which enhancescholine acetyltransferaseactivity in the hippocampus in the rat.

IC50& Target

Choline acetyltransferase[1]

体外研究
(In Vitro)

ZSET-845 has no inhibitory action on AChE activity and enhances choline acetyltransferase (ChAT) activity in NB-1 cells[1].

体内研究
(In Vivo)

Treatment with ZSET-845 at the dose of 0.01, 0.1 and 1 mg/kg significantly ameliorates impaired performance caused by scopolamine. Oral administration of ZSET-845 causes an increase in ChAT activity in the hippocampus. In the hippocampus, ZSET-845 (0.01, 0.1 or 1 mg/kg) significantly increases ChAT activity (112%, 113.8% or 108.7%, respectively) compared with matched vehicle-injected control rats[1]. Oral administration of ZSET845 at a dose of 1 or 10 mg/kg ameliorates learning impairment in passive avoidance task and enhanced ChAT activity in the basal forebrain, medial septum and hippocampus, and increases in the number of ChAT-immunoreactive cells in the medial septum in Ab-treated rats to the levels of vehicle-injected control rats[2].

分子量

314.38

Formula

C21H18N2O

CAS 号

324077-62-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.