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4-Hydroxynonenal-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-Hydroxynonenal-d3图片
CAS NO:148706-06-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
4-HNE-d3
产品介绍
4-Hydroxynonenal-d3 (4-HNE-d3) 是 4-Hydroxynonenal 的氘代物。4-Hydroxynonenal (4-HNE) 是一种 α,β 不饱和羟基烯醛,是一种氧化/亚硝化应激生物标志物。4-Hydroxynonenalal 是ALDH2的底物和抑制剂。4-Hydroxynonenalal 可以调节许多信号传导过程,主要是通过与蛋白质,核酸和膜脂质中具有亲核官能团的共价加合物形成的。4-Hydroxynonenalal 通过线粒体在癌症中起重要作用。
生物活性

4-Hydroxynonenal-d3 (4-HNE-d3) is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor ofacetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role incancerthrough mitochondria[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

159.24

Formula

C9H13D3O2

CAS 号

148706-06-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.