CAS NO: | 532-91-2 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 532-91-2 |
别名 | 6-甲氧基-2-苯唑啉酮,6-Methoxy-2-benzoxazolinone; 6-MBOA |
Canonical SMILES | O=C1OC2=CC(OC)=CC=C2N1 |
分子式 | C8H7NO3 |
分子量 | 165.15 |
溶解度 | DMSO : ≥ 30 mg/mL (181.65 mM) |
储存条件 | Store at 4°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37℃ in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo: [1]. Lee HJ, et al. Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin. Arch Pharm Res. 2015;38(5):620-7. [2]. Rahman M Hafizur, et al. Coixol Exerts an Exclusive Glucose-dependent Insulinotropic Effect in βTC-6Cells. Hafizur et al., J Cytol Histol 2015, 6:3 |