您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Anagrelide HCl
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Anagrelide HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anagrelide HCl图片
CAS NO:58579-51-4
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)292.55
FormulaC10H7Cl2N3O.HCl
CAS No.58579-51-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 14 mg/mL (47.9 mM)
Water:<1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride

InChi Key: TVWRQCIPWUCNMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H

SMILES Code: O=C1NC2=NC3=C(C(Cl)=C(Cl)C=C3)CN2C1.[H]Cl

SynonymsBL-4162A; Anagrelide hydrochloride; BL 4162A; BL-4162A; BL4162A; Agrylin; Xagrid; GALE-401; Thromboreductin
实验参考方法
In Vitro

In vitro activity: Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes.


Cell Assay: Anagrelide is an established platelet-reducing drug. Studies have also investigated the effects of anagrelide on platelets, indicating that platelet function is as important as platelet counts in ET

In Vivo
Animal model
Formulation & Dosage
References

Semin Thromb Hemost. 1997;23(4):379-83; N Engl J Med. 1988 May 19;318(20):1292-4.