CAS NO: | 58579-51-4 |
规格: | ≥98% |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1g | 电议 |
Molecular Weight (MW) | 292.55 |
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Formula | C10H7Cl2N3O.HCl |
CAS No. | 58579-51-4 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 14 mg/mL (47.9 mM) |
Water:<1 mg/mL | |
Ethanol: <1 mg/mL | |
Other info | Chemical Name: Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride InChi Key: TVWRQCIPWUCNMI-UHFFFAOYSA-N InChi Code: InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H SMILES Code: O=C1NC2=NC3=C(C(Cl)=C(Cl)C=C3)CN2C1.[H]Cl |
Synonyms | BL-4162A; Anagrelide hydrochloride; BL 4162A; BL-4162A; BL4162A; Agrylin; Xagrid; GALE-401; Thromboreductin |
In Vitro | In vitro activity: Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes. Cell Assay: Anagrelide is an established platelet-reducing drug. Studies have also investigated the effects of anagrelide on platelets, indicating that platelet function is as important as platelet counts in ET |
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In Vivo | |
Animal model | |
Formulation & Dosage | |
References | Semin Thromb Hemost. 1997;23(4):379-83; N Engl J Med. 1988 May 19;318(20):1292-4. |