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Camalexin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Camalexin图片
CAS NO:135531-86-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Camalexin 是一种从 Camelina sativa (Cruciferae) 中分离出来的植物抗毒素,具有抗菌、抗真菌、抗增殖和抗癌活性。
Cas No.135531-86-1
化学名3-(2-thiazolyl)-1H-indole
Canonical SMILESC1(C(C2=NC=CS2)=CN3)=C3C=CC=C1
分子式C11H8N2S
分子量200.3
溶解度DMF: 14 mg/ml,DMSO: 33 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.