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L-368,899 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-368,899 hydrochloride图片
CAS NO:160312-62-9
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
L-368,899 hydrochloride 是一种具有口服活性的选择性 OT (oxytocin ) receptor 拮抗剂，对大鼠和人类子宫的 IC50 分别为 8.9 和 26 nM。
Cas No.160312-62-9
化学名(S,Z)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanimidic acid hydrochloride
Canonical SMILESCC1=CC=CC=C1N2CCN(S(C[C@]34CC[C@](C(C)4C)([H])C[C@]3([H])/N=C(O)/[C@](N)([H])CCS(C)(=O)=O)(=O)=O)CC2.Cl
分子式C26H42N4O5S2.HCl
分子量591.23
溶解度DMSO: 100 mM,Water: 100 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.

L-368,899 hydrochloride is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368,899 is less active on vasopressin receptor in human liver and kidney, rat liver and kidney (IC50, 510 nM, 960 nM, 890 nM, 2400 nM, respectively)[1].

References:
[1]. Williams PD, et al. 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor. J Med Chem. 1994 Mar 4;37(5):565-71.