Enalapril

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Enalapril

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	75847-73-3
包装:	500mg
市场价:	500元

产品名称

依那普利
MK-421

产品介绍

Enalapril (MK-421) 是一种血管紧张素转换酶(ACE)抑制剂，可用于高血压疾病的研究。

生物活性

Enalapril (MK-421) is anangiotensin-converting enzyme(ACE)inhibitor, can be used for hypertensive diseases research^[1]^[2].

体外研究
(In Vitro)

Enalapril (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity^[1].
Enalapril (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum^[2].
Pure Enalapril has better thermal stability than pure Enalapril^[3].

Apoptosis Analysis^[2]

Cell Line:	Human umbilical vein ECs (HUVECs)
Concentration:	50 μM
Incubation Time:	24 hours
Result:	Inhibited the induction of apoptosis by patient serum.

体内研究
(In Vivo)

Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice^[4].

Animal Model:	Male NMRI mice 20-40 g^[4]
Dosage:	0.03 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.

Clinical Trial

分子量

376.45

Formula

C₂₀H₂₈N₂O₅

CAS 号

75847-73-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.