Enpp/Carbonic anhydrase-IN-2

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包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Enpp/Carbonic anhydrase-IN-2 (compound 1i) 是一种有效的Enpp和carbonic anhydrase抑制剂，对 NPP1、NPP2、NPP3、CA-IX, CA-XII 的IC₅₀值分别 1.13、 1.07、 0.74、 0.33、 0.68。Enpp/Carbonic anhydrase-IN-2 对癌细胞具有抗增殖活性，对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-2 诱导细胞凋亡 (< a href="Apoptosis" target="_blank">Apoptosis)。

生物活性

Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potentEnppandcarbonic anhydraseinhibitor withIC₅₀s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity forcancercells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces< a href="apoptosis" target="_blank">Apoptosis^[1].

IC₅₀& Target^[1]

CA Ⅸ

0.33 μM (IC₅₀)

CA XII

0.68 μM (IC₅₀)

NPP1

1.13 μM (IC₅₀)

NPP2

1.07 μM (IC₅₀)

NPP3

0.74 μM (IC₅₀)

体外研究
(In Vitro)

Enpp/Carbonic anhydrase-IN-2(compound 1e) (0-100 μM; ) 抑制癌细胞生长，对 K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D 细胞的 IC₅₀值分别为 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 μM^[1].
Enpp/Carbonic anhydrase-IN-2 (0-2 μM) 对正常乳腺上皮细胞 (HME1) 和正常皮肤成纤维细胞 (F180) 显示低细胞毒性，IC₅₀值均大于 50 μM^[1].
Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 μM) 以剂量依赖的方式诱导 K-562 细胞凋亡^[1]。

Cell Proliferation Assay^[1]

Cell Line:	K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells
Concentration:	0-100 μM
Incubation Time:
Result:	Inhibited the cell growth with IC₅₀s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 μM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.

Apoptosis Analysis^[1]

Cell Line:	K-562 cells
Concentration:	0.58, 1.16 μM
Incubation Time:
Result:	Induced apoptosis in a dose-dependent manner.

分子量

429.50

Formula

C₂₃H₂₄FNO₄S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.