CAS NO: | 354813-19-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Balicatib (AAE581) is a potent, orally active and selectivecathepsin Kinhibitor withIC50values of 22, 61, 48, 2900 nM forcathepsin K,cathepsin B,cathepsin L,cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis[1][2]. | ||||||||||||||||
IC50& Target[2] |
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体外研究 (In Vitro) | Balicatib (0-10 μM) shows less than 1.5-fold accumulation of Type I collagen at concentrations up to 10 μM in human dermal fibroblasts[2]. | ||||||||||||||||
体内研究 (In Vivo) | Balicatib (0, 3, 10, 50 mg/kg; Oral gavage; twice daily for 18 months) partially prevented ovariectomyinduced changes in bone mass, inhibited bone turnover at most sites, and had an stimulatory effect on periosteal bone formation in cynomolgus monkeys[1].
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Clinical Trial | |||||||||||||||||
分子量 | 411.54 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H33N5O2 | ||||||||||||||||
CAS 号 | 354813-19-7 | ||||||||||||||||
中文名称 | 巴利卡替 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 75 mg/mL(182.24 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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