CAS NO: | 866893-90-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Aftin-4 is anAmyloid-β42(Aβ42) inducer. | ||||||||||||||||
IC50& Target | Amyloid-β[1] | ||||||||||||||||
体外研究 (In Vitro) | Aftin-4 selectively and potently increases Aβ1-42in N2a cells, primary neurons, and brain lysates, with an EC50value around 30 μM[1]. | ||||||||||||||||
体内研究 (In Vivo) | Aftin-4 increases Aβ1-42levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40or Aβ1-42is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42content, up to +216% at the highest dose tested[1]. | ||||||||||||||||
分子量 | 368.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H28N6O | ||||||||||||||||
CAS 号 | 866893-90-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(271.39 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|