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RAGE antagonist peptide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1092460-91-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
RAGE antagonist peptide 是一种晚期糖基化终产物 (RAGE) 拮抗剂。RAGE antagonist peptide (RAP) 可阻断 RAGE 和几个重要配体 HMGB-1、S100P、S100A4 的结合。RAGE antagonist peptide (RAP) 具有抗肿瘤和抗炎活性。
生物活性

RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].

体外研究
(In Vitro)

RAGE antagonist peptide (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro[1].

体内研究
(In Vivo)

RAGE antagonist peptide (RAP, 100 μg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo[1].
RAGE antagonist peptide (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth[1].
In mice bearing asthma, RAGE antagonist peptide (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function[2].

Animal Model:Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice[1].
Dosage:100 μg.
Administration:Intratumoral delivery (or intraperitoneally).
Result:Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection.
分子量

1272.56

Formula

C57H101N13O17S

CAS 号

1092460-91-7

Sequence Shortening

Ac-ELKVLMEKEL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.