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Donepezil-d4 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Donepezil-d4 hydrochloride图片
CAS NO:1219798-88-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
E2020-d4
产品介绍
Donepezil-d4 hydrochloride (E2020-d4) 是 Donepezil hydrochloride 的氘代物。Donepezil Hydrochloride (E2020) 是一种可逆的选择性AChE抑制剂,对AChE 的IC50为 6.7 nM。对 AChE 的选择性高于 BuChE。Donepezil Hydrochloride对 Aβ42 神经毒性具有神经保护作用。
生物活性

Donepezil-d4 hydrochloride (E2020-d4) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selectiveAChEinhibitor with anIC50of 6.7 nM forAChEactivity. Donepezil shows high selectivity forAChEover BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

419.98

性状

Solid

Formula

C24H26D4ClNO3

CAS 号

1219798-88-5

中文名称

盐酸多奈哌齐 d4 (盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month