Protriptyline

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Protriptyline

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

438-60-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Protriptyline 是一种有效的抗抑郁剂 (antidepressant)。Protriptyline 抑制乙酰胆碱酯酶活性，IC₅₀值为 0.06 mM，并抑制 Aβ 自组装。Protriptyline 可用于治疗抑郁症和阿尔茨海默病。

生物活性

Protriptyline is a potentantidepressantagent. Protriptyline inhibitsAChEactivity withIC₅₀value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease^[1]^[2]^[3].

体外研究
(In Vitro)

Protriptyline (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells^[2].

Cell Cytotoxicity Assay^[2]

Cell Line:	PC3 cells
Concentration:	50, 60 and 70 μM
Incubation Time:	24 hours
Result:	Decreased cell viability in a concentration-dependent manner.

体内研究
(In Vivo)

Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats^[3].

Animal Model:	Rat model of AD^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; for 21 days.
Result:	Reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation. Improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression.

Clinical Trial

分子量

263.38

Formula

C₁₉H₂₁N

CAS 号

438-60-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.