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DHMEQ racemate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DHMEQ racemate图片
CAS NO:287194-38-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
rel-DHMEQ
产品介绍
DHMEQ racemate 是一种NF-κB抑制剂。 DHMEQ racemate 抑制 NF-κB 的活性低于 (-)-DHMEQ。
生物活性

DHMEQ racemate is aNF-κBinhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

IC50& Target[1]

NF-κB

 

体外研究
(In Vitro)

DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1].

体内研究
(In Vivo)

The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1].

分子量

261.23

Formula

C13H11NO5

CAS 号

287194-38-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : ≥ 32 mg/mL(122.50 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.8280 mL19.1402 mL38.2804 mL
5 mM0.7656 mL3.8280 mL7.6561 mL
10 mM0.3828 mL1.9140 mL3.8280 mL