Tin-protoporphyrin IX

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CAS NO:

14325-05-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品名称

锡原卟啉IX
SnPPIX
Stannous protoporphyrin IX

产品介绍

Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。

生物活性

Tin-protoporphyrin IX (SnPPIX) is a potentHeme oxygenase-1 (HO-1)inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model^[1].

IC₅₀& Target

IC50: Heme oxygenase-1 (HO-1)^[1]

体外研究
(In Vitro)

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM^[1].

Cell Viability Assay^[1]

Cell Line:	Capan-1, CD18/HPAF, PDAC cells
Concentration:	20 μM, 50 μM
Incubation Time:	24 or 72 hours
Result:	Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.

体内研究
(In Vivo)

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P< 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment^[1].

Animal Model:	Male and female athymic nude mice with PDAC cell-derived xenograft tumors^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result:	Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).

分子量

750.26

性状

Solid

Formula

C₃₄H₃₂Cl₂N₄O₄Sn

CAS 号

14325-05-4

中文名称

锡原卟啉IX

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

0.1 M NaOH : 14.29 mg/mL(19.05 mM;ultrasonic and adjust pH to 12 with NaOH)

DMF : 1 mg/mL(1.33 mM;Need ultrasonic and warming)

DMSO : 0.5 mg/mL(0.67 mM;Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.3329 mL	6.6644 mL	13.3287 mL
5 mM	0.2666 mL	1.3329 mL	2.6657 mL
10 mM	0.1333 mL	0.6664 mL	1.3329 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。