CAS NO: | 20784-50-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Isobavachalcone (Corylifolinin) is derived fromPsoralea corylifolia Linn.and is a potent inhibitor ofAktsignaling pathway, which inducesapoptosisin humancancercells (Inhibits OVCAR-8 cell growth with anIC50value of 7.92 μM). Isobavachalcone also inducesReactive Oxyen Species (ROS)generation in OVCAR-8 cells and has exhibitcanceranti-promotive and anti-proliferative activity[1]. | ||||||||||||||||||||||||
IC50& Target | IC50: 7.92 μM (OVCAR-8 cell)[1] | ||||||||||||||||||||||||
体外研究 (In Vitro) | Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively[1]. Cell Proliferation Assay[1]
Western Blot Analysis[1]
Apoptosis Analysis[1]
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体内研究 (In Vivo) | Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1].
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分子量 | 324.37 | ||||||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||||||
Formula | C20H20O4 | ||||||||||||||||||||||||
CAS 号 | 20784-50-3 | ||||||||||||||||||||||||
中文名称 | 补骨脂乙素;补骨酯乙素;异补骨脂查耳酮;异补骨脂查尔酮 | ||||||||||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||||||||||
溶解性数据 | In Vitro: DMSO : 11 mg/mL(33.91 mM;Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |