Deoxynyboquinone, an excellentNQO1substrate, is a potent antineoplastic agent. Deoxynyboquinone inducesapoptosisincancercell lines. Deoxynyboquinone killscancercells through oxidative stress andreactive oxygen species(ROS) formation^[1][2][3].

Apoptosis^[2][3]; ROS^[4]

Deoxynyboquinone (DNQ; 72h) potently induces the death of cancer cells (SK-MEL-5, MCF-7, HL-60, HL-60/ADR) in culture, with IC₅₀values between 16 and 210 nM^[2].
Deoxynyboquinone is still able to induce cancer cell death under hypoxic conditions (HeLa cell; IC₅₀: 5.1 μM)^[2].
Deoxynyboquinone (group B1; 0.5 μM; 3, 6, 24 hours) potently induces apoptosis in cancer cell lines (MCF-7, HL-60) through cytochrome c release^[3].

Deoxynyboquinone (2.5, 5, and 10 mg/kg; every other day for 5 injections; i.v. for day 2-18) shows antitumor efficacy confirmed by overall survival (at 5 mg/kg), at a 6-fold lower dose than β-lapachone (30 mg/kg)^[4].

284.27

Solid

C₁₅H₁₂N₂O₄

96748-86-6

Room temperature in continental US; may vary elsewhere.

DMSO : 4 mg/mL(14.07 mM;ultrasonic and warming and heat to 60℃)

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