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Dyphylline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dyphylline图片
CAS NO:479-18-5
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)254.24
FormulaC10H14N4O4
CAS No.479-18-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 51 mg/mL (200.6 mM)
Water:<1 mg/mL
Ethanol: 51 mg/mL (200.6 mM)
Solubility (In vivo)

Chemical Name: 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione

InChi Key: KSCFJBIXMNOVSH-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

SMILES Code: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O

SynonymsDiprophylline; Dyphylline; Lufyllin; Corphyllin; Neothylline
实验参考方法
In Vitro

In vitro activity: Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles

In Vivo
Animal model
Formulation & Dosage
References

[1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

[2]. Iancu L, et al. Trials with xanthine derivatives in systemic treatment of psoriasis. Dermatologica. 1979;159(1):55-61.