Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selectivepan-Aktinhibitor withIC₅₀values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

Uprosertib inhibits Akt1/2/3 with the K_dvalues of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding^[1].

465.71

C₁₈H₁₇Cl₃F₂N₄O₂

1047635-80-2

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