CAS NO: | 264218-23-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | SB 415286 is a potent and selective cell permeable inhibitor ofGSK-3α, with anIC50of 77.5 nM, and aKiof 30.75 nM; SB 415286 is equally effective at inhibiting humanGSK-3αandGSK-3β. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | SB 415286 (SB-415286) inhibits human GSK-3α with an IC50of 77.5 nM, and a Kiof 30.75 nM. SB-415286 stimulates glycogen synthesis in the Chang human liver cell line with EC50of 2.9 μM. SB-415286 stimulates glycogen synthase activity in Chang human liver cells. SB-415286 induces transcription of a β-catenin-LEF/TCF regulated reporter gene in HEK293 cells[1]. SB 415286 (SB-415286, 5-44 μM) attenuates B65 cell loss mediated by 1 mM H2O2. SB-415286 (5-44 μM) causes a significant dose-dependent decrease in the fluorescence intensity of DCF, and attenuates B65 ROS production as mediated by 1 mM H2O2. SB-415286 (5-44 μM) also attenuates ROS production in CGN mediated by 1 mM H2O2[2]. SB-415286 (50 μM) induces a substantial suppression of immunoprecipitated GSK3 activity by 97%[3]. | ||||||||||||||||
分子量 | 359.72 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H10ClN3O5 | ||||||||||||||||
CAS 号 | 264218-23-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(277.99 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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