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BIP-135
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIP-135图片
CAS NO:941575-71-9
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
BIP-135 是一个高效、选择性的,ATP 竞争性的GSK-3抑制剂,对 GSK-3α 和 GSK-3β 作用的IC50值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。
生物活性

BIP-135 is a potent and selective ATP-competitiveGSK-3inhibitor, withIC50s of 16 nM and 21 nM forGSK-3αandGSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].

IC50& Target

GSK-3α

16 nM (IC50)

GSK-3β

21 nM (IC50)

体外研究
(In Vitro)

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1].
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1].

Western Blot Analysis[1]

Cell Line:Human SMA fibroblasts
Concentration:20 μM, 25 μM, 30 μM
Incubation Time:72 hours
Result:Led to a 7-fold increase in SMN levels at 25 μM.
体内研究
(In Vivo)

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy[1].

Animal Model:Male and female SMN2+/+, SMN2Δ7+/+, Smn+/–mice[1]
Dosage:75 mg/kg
Administration:Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:Caused a modest extension in the median survival of SMA KO animals by two days.
分子量

421.24

性状

Solid

Formula

C21H13BrN2O3

CAS 号

941575-71-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL(148.37 mM;ultrasonic and warming and heat to 70℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.3739 mL11.8697 mL23.7394 mL
5 mM0.4748 mL2.3739 mL4.7479 mL
10 mM0.2374 mL1.1870 mL2.3739 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。