CAS NO: | 941575-71-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BIP-135 is a potent and selective ATP-competitiveGSK-3inhibitor, withIC50s of 16 nM and 21 nM forGSK-3αandGSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].
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分子量 | 421.24 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H13BrN2O3 | ||||||||||||||||
CAS 号 | 941575-71-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 62.5 mg/mL(148.37 mM;ultrasonic and warming and heat to 70℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |