GS87

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GS87

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

919936-70-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

GS87 是一种高度特异性的GSK3抑制剂，对 GSK3α 和 GSK3β 的IC₅₀分别为 415nM 和 521nM。GS87 通过有效地激活 GSK3 依赖性信号成分(包括 MAPK 信号)诱导急性髓性白血病 (AML) 细胞系的分化。GS87 比 Lithium 和 SB415285 (SB) 更有效地调节参与细胞增殖和分化的关键 GSK3 靶蛋白。GS87 具有作为非早幼粒细胞 AML 分化剂研究的潜力。

生物活性

GS87 is a highly specific and potentGSK3inhibitor withIC₅₀s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research^[1].

IC₅₀& Target^[1]

GSK3α

415 nM (IC₅₀)

GSK3β

521 nM (IC₅₀)

分子量

337.36

Formula

C₁₆H₁₁N₅O₂S

CAS 号

919936-70-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.