CAS NO: | 908-35-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Metyrapone (Su-4885) Tartrate is a potent and orally active11β-hydroxylaseinhibitor and anautophagyactivator, also inhibits the production ofaldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation ofmTORpathway, and interacts withPseudomonas putidacytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression[1][2][3][4][5]. | ||||||||
IC50& Target | 11β-hydroxylase, Aldosterone, CYP450, Autophagy[1][4][5] | ||||||||
体外研究 (In Vitro) | Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress[5]. | ||||||||
体内研究 (In Vivo) | Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage[1].
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Clinical Trial | |||||||||
分子量 | 526.45 | ||||||||
Formula | C22H26N2O13 | ||||||||
CAS 号 | 908-35-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |