CAS NO: | 1033739-92-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3Kinhibitor withIC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα,PI3Kβ,PI3KδandPI3Kγ, respectively. GNE-490 has >200 fold selectivity formTOR(IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breastcancerxenograft model[1]. | ||||||||||||||||
IC50& Target[1] |
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分子量 | 386.47 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H22N6O2S | ||||||||||||||||
CAS 号 | 1033739-92-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(258.75 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |