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PI3K/mTOR Inhibitor-9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI3K/mTOR Inhibitor-9图片
CAS NO:1392421-71-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PI3K/mTOR Inhibitor-9 (Compound 1) 是一种有效的mTORPI3K抑制剂,对 mTOR、PI3Kα、PI3Kγ 和 PI3Kδ 的IC50分别为 38 nM、6.6 μM、6.6 μM 和 0.8 μM。
生物活性

PI3K/mTOR Inhibitor-9 (Compound 1) is a potentmTORandPI3Kinhibitor withIC50values of 38 nM, 6.6 μM, 6.6 μM and 0.8 μM againstmTOR(phospho-S6 cellular assay),PI3Kα,PI3KγandPI3Kδ, respectively[1].

IC50& Target

mTOR

38 nM (IC50, phospho-S6 cellular assay)

PI3Kα

6.6 μM (IC50)

PI3Kβ

>10 μM (IC50)

PI3Kγ

6.6 μM (IC50)

PI3Kδ

0.8 μM (IC50)

mTOR

16 nM (IC50, Ser240/244 cellular assay)

体外研究
(In Vitro)

PI3K/mTOR Inhibitor-9 (Compound 1) shows good selectivity over the related kinases PI3Kα, β and γ, although with lower selectivity over PI3Kδ[1].
PI3K/mTOR Inhibitor-9 inhibits CYP2D6 (IC50= 1.98 μM) and shows time-dependent inhibition (TDI) of CYP3A4 (rate of enzyme inhibition, kobs= 0.080 /min)[1].
PI3K/mTOR Inhibitor-9 shows good permeability with no sign of P-gp efflux (B-A/A-B: 0.95)[1].

分子量

433.51

Formula

C23H27N7O2

CAS 号

1392421-71-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.