您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > PI3K-IN-37
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PI3K-IN-37
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI3K-IN-37图片
CAS NO:1257547-40-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PI3K-IN-37 (Example 84.1) 是一种PI3K α/β/δ抑制剂,其IC50分别为 6、8、4 nM。PI3K-IN-37 可抑制mTOR(IC50=4 nM)。
生物活性

PI3K-IN-37 (Example 84.1) is aPI3Kα/β/δinhibitor withIC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibitmTOR(IC50=4 nM)[1].

IC50& Target[1]

PI3Kδ

4 nM (IC50)

mTOR

4 nM (IC50)

PI3Kα

6 nM (IC50)

PI3Kβ

8 nM (IC50)

体外研究
(In Vitro)

PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1].
PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1].

Cell Viability Assay[1]

Cell Line:Rat1 cells
Concentration:0.005-10 μM
Incubation Time:30 min
Result:Inhibited Pl3-kinase isoforms alpha, beta or delta phosphorylation with the IC50s of<5 nM, 8 nM, and 18 nM, respectively.

Cell Viability Assay[1]

Cell Line:TSC1-/- MEF cells
Concentration:0.005-1 μM
Incubation Time:60 min
Result:Inhibited S6 Ribosomal Protein phosphorylation (IC50=2 nM).
分子量

442.51

Formula

C25H26N6O2

CAS 号

1257547-40-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.