您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > PI3K-IN-22
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PI3K-IN-22
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI3K-IN-22图片
CAS NO:1202884-94-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PI3K-IN-22 是一种PI3Kα/mTOR双重激酶抑制剂。PI3K-IN-22 对 PI3Kα 和 mTOR 的IC50s 值分别为 0.9、0.6 nM。PI3K-IN-22 可用于癌症研究。
生物活性

PI3K-IN-22 is aPI3Kα/mTORdual kinase inhibitor. PI3K-IN-22 hasIC50s of 0.9, 0.6 nM forPI3KαandmTOR, respectively. PI3K-IN-22 can be used for the research ofcancer[1].

IC50& Target[1]

PI3Kα

0.9 nM (IC50)

mTOR

0.6 nM (IC50)

体外研究
(In Vitro)

PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC50s of<3.0 and 13.0 nM[1].

体内研究
(In Vivo)

PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies[1].
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h[1].

Animal Model:MDA361 tumor xenograft nude mice model[1]
Dosage:50, 25, 10 mg/kg
Administration:i.v., once daily for 5 days weekly (2 rounds)
Result:Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32.
Exhibited tumor growth inhibition in 25 and 10 mg/kg.
分子量

624.66

Formula

C31H35F3N8O3

CAS 号

1202884-94-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.