CAS NO: | 1949802-49-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dualPI3K/mTORinhibitor withIC50s of 20/376/204/46 nM and 186 nM forPI3Kα/PI3Kβ/PI3Kγ/PI3KδandmTOR, respectively[1]. Antitumor activity[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | PI3K/mTOR Inhibitor-1 (Compound 26) also exhibits potent functional suppression of AKT phosphorylation (IC50=196 nM)[1]. Cell Proliferation Assay[1]
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体内研究 (In Vivo) | PI3K/mTOR Inhibitor-1 (Compound 26) produces 54.4% tumor growth inhibition (TGI) with daily oral doses of 3.75 mg/kg for 27 days. The 7.5 mg/kg group of PI3K/mTOR Inhibitor-1 displays more significant TGI (72.9%). All animals survive after 27-day treatment, whereas 15% weigh loss is observed in PI3K/mTOR Inhibitor-1, 7.5 mg/kg group[1].
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分子量 | 407.46 | ||||||||
Formula | C18H22FN5O3S | ||||||||
CAS 号 | 1949802-49-6 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |