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IPI-3063
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IPI-3063图片
CAS NO:1425043-73-7
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
IPI-3063 是一种有效的选择性PI3K p110δ抑制剂,IC50为 2.5±1.2 nM。
生物活性

IPI-3063 is a potent and selectivePI3Kp110δinhibitor with anIC50of 2.5 ± 1.2 nM.

IC50& Target[1]

p110δ

2.5 nM (IC50)

p110α

1170 nM (IC50)

p110β

1508 nM (IC50)

p110γ

2187 nM (IC50)

体外研究
(In Vitro)

IPI-3063 inhibits p110α, p110β, and p110γ with IC50s of 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1. IPI-3063 is a p110δ selective compound with an IC50=0.1 nM in p110δ-specific cell-based assays and cellular IC50values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very potent in reducing p-AKT (significant effect at 1 nM). IPI-3063 also reduces p-ERK1/2 with a significant effect at 10 nM. IPI-3063 is very potent, achieving a significant decrease in B cell survival when present at 10 nM[1].

分子量

455.51

性状

Solid

Formula

C25H25N7O2

CAS 号

1425043-73-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 62.5 mg/mL(137.21 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.1953 mL10.9767 mL21.9534 mL
5 mM0.4391 mL2.1953 mL4.3907 mL
10 mM0.2195 mL1.0977 mL2.1953 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。