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Irsogladine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Irsogladine图片
CAS NO:57381-26-7
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)256.09
FormulaC9H7Cl2N5
CAS No.57381-26-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 2 mg/mL (7.8 mM)
Water:<1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine

SMILES Code: NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1

SynonymsMN1695; MN 1695; Gaslon; MN-1695; Irsogladine maleate;
实验参考方法
In Vitro

In vitro activity: Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. Irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions

In VivoIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice.
Animal modelMice
Formulation & Dosage300 and 500 mg/kg
References

J Surg Res. 1998 Jul 1;77(2):126-31; Pancreas. 2002 Nov;25(4):373-7; Life Sci. 2004 Aug 27;75(15):1833-42.