PI3K-IN-2

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PI3K-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1403458-28-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PI3K-IN-2 (compound 10) 是一种口服有效的PI3Kβ/δ抑制剂 (IC₅₀=7.1/8.6 nM)，与 PI3Kσ、PI3Kγ 相比 (IC₅₀=13/190 nM)，选择性更好。

生物活性

PI3K-IN-2 (compound 10) is a potent and orally activePI3Kβ/δ(IC₅₀=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ andPI3Kγ(IC₅₀=13/190 nM, respectively)^[1].

IC₅₀& Target

PI3Kα

13 nM (IC₅₀)

PI3Kβ

7.1 nM (IC₅₀)

PI3Kδ

190 nM (IC₅₀)

PI3Kγ

8.6 nM (IC₅₀)

体外研究
(In Vitro)

PI3K-IN-2 (compound 10) shows PI3Kβ cell IC₅₀1.1 nM in phosphatase and tensin homolog (PTEN) null MDA-MB-468 cell and PI3Kδ cellIC₅₀14 nM in Jeko-1 B-cell^[1].

体内研究
(In Vivo)

PI3K-IN-2 shows profound pharmacodynamic modulation of AKT phosphorylation in PTEN-deficient PC3 prostate tumour bearing mice after oral administration and gave significant inhibition of tumour growth in the same xenograft model^[1].

分子量

525.54

Formula

C₂₈H₂₉F₂N₃O₅

CAS 号

1403458-28-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.