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PI3K/VEGFR2-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI3K/VEGFR2-IN-1图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PI3K/VEGFR2-IN-1 是一种有效的双重PI3K/VEGFR2抑制剂,抑制 PI3K 和 VEGFR2 的IC50值分别为 2.21 和 68 μM。PI3K/VEGFR2-IN-1 诱导细胞凋亡 (apoptosis)。PI3K/VEGFR2-IN-1 可用于癌症的研究。
生物活性

PI3K/VEGFR2-IN-1 is a potent dualPI3K/VEGFR2inhibitor withIC50values of 2.21 and 68 μM forPI3Kand VEGFR2, respectively. PI3K/VEGFR2-IN-1 inducesapoptosis. PI3K/VEGFR2-IN-1 can be used in research ofcancer[1].

IC50& Target[1]

PI3K

2.21 μM (IC50)

VEGFR2

68 μM (IC50)

体外研究
(In Vitro)

PI3K/VEGFR2-IN-1 (compound 8; 1.56-100 μM; 24 h; HePG2, MCF-7, Hela, and PC3 cells) inhibits cell proliferative in a dose-dependent manner[1].
PI3K/VEGFR2-IN-1 (10 mg/mL; 24 h; MCF-7 and Hela cells) arrests cell cycle at G1/S phase and induces apoptosis[1].

Cell Viability Assay[1]

Cell Line:HePG2, MCF-7, Hela, and PC3 cells
Concentration:1.56-100 μM
Incubation Time:24 hours
Result:Had antitumor activity with IC50values of 7.94, 9.73 , 11.58, and 17.49 μM for Hela, HePG2, MCF-7 and PC3 cells, respectively.

Cell Cycle Analysis[1]

Cell Line:MCF-7 cells
Concentration:10 mg/mL
Incubation Time:24 hours
Result:Arrested cell cycle in G1/S phase at 24 h by 51.23%.

Cell Cycle Analysis[1]

Cell Line:MCF-7 and Hela cells
Concentration:10 mg/mL
Incubation Time:24 hours
Result:Enhanced late apoptotic induction with 14.11% at Hela cells.
分子量

343.83

Formula

C17H14ClN3OS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.