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PI3K-IN-33
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI3K-IN-33图片
CAS NO:2458163-92-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PI3K-IN-33 (Compound 6e) 是一种高选择性的PI3K抑制剂,PI3K-α,PI3K-β 和 PI3K-δ 的IC50值分别为 11.73、6.09 和 11.18 μM。PI3K-IN-33 阻滞细胞周期于 G2/M 期并诱导细胞凋亡。PI3K-IN-33 可用于白血病研究。
生物活性

PI3K-IN-33 (Compound 6e) is a highly selectivePI3Kinhibitor withIC50values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and inducesapoptosis. PI3K-IN-33 can be used in leukemia research[1].

IC50& Target[1]

PI3Kα

11.73 μM (IC50)

PI3Kβ

6.09 μM (IC50)

PI3Kδ

11.18 μM (IC50)

体外研究
(In Vitro)

PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].
PI3K-IN-33 (Compound 6e) induces cell cycle arrest toward the G2-M phase (30.3%) and leads to DNA synthesis and apoptosis[1].
PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) results in apoptotic with 12.13% of cells in the early and latest age[1].

Cell Cytotoxicity Assay[1]

Cell Line:Leukemia SR cell lines.
Concentration:10 μM
Incubation Time:48 hours
Result:Antiproliferative activity with values of 0.76 μM.
分子量

493.36

Formula

C23H21BrN6O2

CAS 号

2458163-92-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.