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Flupentixol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flupentixol图片
CAS NO:2709-56-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Flupenthixol
产品介绍
Flupentixol 是一种具有口服活性的D1/D2多巴胺受体拮抗剂和新型PI3K抑制剂 (PI3KαIC50=127 nM)。Flupentixol 具有对癌细胞的抗增殖活性并诱导细胞凋亡。Flupentixol 也可用于精神分裂症、焦虑和抑郁症的研究。
生物活性

Flupentixol is an orally activeD1/D2dopamine receptorantagonist and newPI3Kinhibitor (PI3KαIC50=127 nM). Flupentixol shows anti-proliferative activity tocancercells and inducesapoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].

IC50& Target[3]

D1Receptor

 

D2Receptor

 

PI3Kα

127 nM (IC50)

体外研究
(In Vitro)

Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner[3].
Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells[3].
Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels[3].

Cell Viability Assay[3]

Cell Line:A549, H661, SK-SEM-1, and NCAL-H520 cells
Concentration:2.5, 5, 10, 20, or 40 μM
Incubation Time:72 hours
Result:Showed the IC50s of 5.708 μM and 6.374 μM for A549 and H661 cells, respectively.

Apoptosis Analysis[3]

Cell Line:A549 and H661 cells
Concentration:5, 10, 20 and 40 μM
Incubation Time:24 hours
Result:Increased the percentage of cells in early apoptosis compared with the negative control in both A549 and H661 (p< 0.05). Induced the cleavage of PARP and caspase-3 in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line:H661 and A549 cells
Concentration:2.5, 5, 10, and 15 μM
Incubation Time:24 hours
Result:Decreased AKT phosphorylation levels in a dose-dependent manner, decreased the expression levels of Bcl-2.
体内研究
(In Vivo)

Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice[3].

Animal Model:BALB/C nude mice injected with A549 cells[3]
Dosage:40 mg/kg
Administration:Intragastric injection; 40 mg/kg; once daily; 21 days
Result:Reduced tumor volumes compared to the vehicle control (p<0.05), reduced tumor weights by 64.1% (p<0.05).
Clinical Trial
分子量

434.52

Formula

C23H25F3N2OS

CAS 号

2709-56-0

中文名称

氟哌噻吨

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.