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GSK2292767
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2292767图片
CAS NO:1254036-66-2
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
GSK2292767 是一种有效和选择性的PI3Kδ的抑制剂,pIC50值为 10.1。GSK2292767 的选择性是其他 PI3K 亚型的 500 倍以上。GSK2292767 可用于呼吸系统疾病的研究。
生物活性

GSK2292767 is a potent and selective inhibitor ofPI3Kδ, with apIC50of 10.1. GSK2292767 showing greater than 500-fold selective over the otherPI3Kisoforms. GSK2292767 can be used for the research of respiratory disease[1].

IC50& Target[1]

PI3Kδ

10.1 (pIC50)

体内研究
(In Vivo)

GSK2292767 exhibits high clearance (50 mL/min/kg) in vivo and low oral bioavailability (F< 2%) in a rat PK study[1].
GSK2292767 (0.01-1 μM) has no effect on QT interval, Tp-e, or QRS and no significant risk of TdP arrhythmias in a rabbit cardiac ventricular wedge assay[1].
GSK2292767 protects against eosinophil recruitment with an ED50of 35 μg/kg in the brown Norway rat acute OVA model of Th2 driven inflammation in the lungs of rats[1].

Clinical Trial
分子量

512.58

Formula

C24H28N6O5S

CAS 号

1254036-66-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.