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ON 146040
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ON 146040图片
CAS NO:1404231-34-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ON 146040 是一种有效的PI3KαPI3Kδ抑制剂,IC50分别约为 14 和 20 nM。ON 146040 也抑制Abl1(IC50<150 nM)。
生物活性

ON 146040 is a potentPI3KαandPI3Kδ(IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibitsAbl1(IC50<150 nM).

IC50& Target[1]

PI3Kα

14 nM (IC50)

PI3Kδ

20 nM (IC50)

PI3Kγ

1 μM (IC50)

PI3Kβ

3 μM (IC50)

体外研究
(In Vitro)

In biochemical testing, ON 146040 inhibits PI3Kα/ PI3Kδ isoforms (IC50≈14 and 20 nM, respectively) without having a major effect on PI3Kβ/ PI3Kγ isoforms (IC50≈3 and 1 μM, respectively). ON 146040 is also found to inhibit Abl1 and several mutant versions of this kinase (IC50<150 nm), although on 146040 is not found to be active against the t315i mutant. represents first dual pi3k and bcr-abl inhibitor that targets stat3 stat5 pathways. disrupts oncogenic activity of both by targeting upstream activators, including α δ isoforms as well wild type mutant bcr-abl. highly potent in killing hematologic tumor cells with ic50values in the 150 to 1,000 nM range. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation are down-regulated in leukemia and myeloma cells[1].

分子量

489.55

Formula

C24H23N7O3S

CAS 号

1404231-34-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.