CAS NO: | 1404231-34-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | ON 146040 is a potentPI3KαandPI3Kδ(IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibitsAbl1(IC50<150 nM). | ||||
IC50& Target[1] |
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体外研究 (In Vitro) | In biochemical testing, ON 146040 inhibits PI3Kα/ PI3Kδ isoforms (IC50≈14 and 20 nM, respectively) without having a major effect on PI3Kβ/ PI3Kγ isoforms (IC50≈3 and 1 μM, respectively). ON 146040 is also found to inhibit Abl1 and several mutant versions of this kinase (IC50<150 nm), although on 146040 is not found to be active against the t315i mutant. represents first dual pi3k and bcr-abl inhibitor that targets stat3 stat5 pathways. disrupts oncogenic activity of both by targeting upstream activators, including α δ isoforms as well wild type mutant bcr-abl. highly potent in killing hematologic tumor cells with ic50values in the 150 to 1,000 nM range. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation are down-regulated in leukemia and myeloma cells[1]. | ||||
分子量 | 489.55 | ||||
Formula | C24H23N7O3S | ||||
CAS 号 | 1404231-34-0 | ||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |