Cbl-b-IN-2

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Cbl-b-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2503325-21-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Cbl-b-IN-2 (Example 8) 是一种口服有效的生物化合物，可抑制泛素蛋白酶体通路中的 E3 酶Casitas b系淋巴瘤原癌基因-b (Cbl-b)。Cbl-b-IN-2 可用于调节免疫系统和易受免疫系统调节的疾病。Cbl-b-IN-2 (Example 8) 还可单独或与一种或多种免疫检查点抑制剂，抗肿瘤剂和放射剂联合应用于癌症。

生物活性

Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzymeCasitas B-lineage lymphoma proto-oncogene-b (Cbl-b)in the ubiquitinproteasomepathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual withcancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent^[1].

体外研究
(In Vitro)

Cbl-b-IN-2 (Example 8) is a Cbl-b inhibitor withIC₅₀values range of 5.1-100 nM and ﹤1 nM in high and low concentration of Cbl-b, respectively^[1].

Cell Viability Assay^[1]

Cell Line:	Immune cell
Concentration:	0.125 nM, 0.15 nM
Incubation Time:	1 h
Result:	Showed Cbl-b activity with an withIC₅₀values range of 5.1-100 nM and ﹤1 nM in high and low concentration of Cbl-b, respectively.

分子量

575.57

Formula

C₂₉H₃₀F₅N₅O₂

CAS 号

2503325-21-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.