Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide basedcereblonligand and a linker used forPROTACBCL-XL degrader XZ739^[1].

XZ739, a CRBN-dependentPROTAC BCL-XL degraderwith aDC₅₀value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediatedapoptosis^[1].

449.45

C₂₁H₂₇N₃O₈

2140807-23-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.