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Palmatine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Palmatine hydrochloride图片
CAS NO:10605-02-4
包装:20mg
市场价:347元

产品介绍
Palmatine hydrochloride 是一种具有口服活性且不可逆的吲哚胺 2,3-双加氧酶 1 (IDO-1) 抑制剂,对 HEK 293-hIDO-1 和 rhIDO-1 的 IC50 值分别为 3 μM 和 15&7#956;M。
Cas No.10605-02-4
别名盐酸巴马汀
化学名2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride
Canonical SMILESCOC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]
分子式C21H22NO4Cl
分子量387.86
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml,Ethanol: 5 mg/ml
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties. IC50 value:Target:In vitro: Experimental set examined the influence of palmatine on osteoblast-like cells in vitro. In the culture supernatant of MC3T3-E1 cells, RANKL and OPG levels were significantly reduced by palmatine addition [1]. In vivo: The first experimentaI set was designed to histologically and biochemically examine mice randomly divided into four groups: sham-operated, OVX, and OVX-palmatine intake groups (1 mg/kg and 10 mg/kg). In palmatine-treated mice, RANKL and OPG expression decreased [1].

References:
[1]. SHINTARO ISHIKAWA, et al. Influence of Palmatine on Bone Metabolism in Ovariectomized Mice and Cytokine Secretion of Osteoblasts.
[2]. Chen-Wen Xiao, er al. Antifungal activity of berberine hydrochloride and palmatine hydrochloride against Microsporum canis -induced dermatitis in rabbits and underlying mechanism. BMC Complement Altern Med. 2015; 15: 177.