Thalidomide-4-OH

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Thalidomide-4-OH

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

5054-59-1

包装与价格：

包装	价格(元)
1 g	电议
5 g	电议
10 g	电议
50 g	电议

产品名称

Cereblon ligand 2
E3 ligase Ligand 2

产品介绍

Thalidomide-4-OH (Cereblon ligand 2) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-4-OH (Cereblon ligand 2) 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

生物活性

Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-basedCereblonligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to formPROTACs^[1].

IC₅₀& Target

Cereblon

体外研究
(In Vitro)

Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. Thalidomide-OH is a putative hydroxylated thalidomide metabolite. Thalidomide-OH has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells^[1].

分子量

274.23

性状

Solid

Formula

C₁₃H₁₀N₂O₅

CAS 号

5054-59-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : ≥ 36.5 mg/mL(133.10 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.6466 mL	18.2329 mL	36.4657 mL
5 mM	0.7293 mL	3.6466 mL	7.2931 mL
10 mM	0.3647 mL	1.8233 mL	3.6466 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。