Thalidomide-5-PEG2-Cl is the Thalidomide-basedcereblonligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to formPROTACs^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

380.78

C₁₇H₁₇ClN₂O₆

2230956-57-5

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