蛋白质/抗原/多肽 >> 重组蛋白
重组甲状腺激素受体相互作用12蛋白
产品介绍 基因名: TRIP12 产品别名: MRD49; TRIP-12; TRIPC; ULF; TRIP12; thyroid hormone receptor interactor 12; thyroid hormone receptor interactor 12; E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase for Arf; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; probable E3 ubiquitin-protein ligase TRIP12; thyroid receptor interacting protein 12; 甲状腺激素受体相互作用12; 背景信息: TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. TRP12 specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). TRP12 was originally identified as a factor that interacts with the thyroid hormone receptor. It was later found to also interact with AAP-BP1, a component of the NEDD8 –activating enzyme, and function as an E3 ubiquitin ligase for AAP-BP1. 标签:His-tag |
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