蛋白质/抗原/多肽 >> 重组蛋白
重组螺旋转录因子OTP蛋白
产品介绍 基因名: Otp 产品别名: Otp; orthopedia homeobox; orthopedia homeobox; homeobox protein orthopedia; orthopedia homolog; 螺旋转录因子OTP; 背景信息: Homeodomain (HD) genes are helix-turn-helix transcription factors that play key roles in the specification of cell fates. OTP (orthopedia homeobox) is a 325 amino acid nuclear protein belonging to the paired homeobox family and Bicoid subfamily. OTP is expressed in neurons, which give rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV) and arcuate (ARN) nuclei. Containing a homeobox DNA-binding domain and a OAR domain, OTP is suggested to be involved in the differentiation of hypothalamic neuroendocrine cells. At early embryonic stages in mice, the expression of SIM2 is downregulated in the absence of OTP, indicating a potential role for OTP as an upstream regulator of SIM2. OTP is highly conserved in evolution and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. 标签:His-tag |
相关产品
|