蛋白质/抗原/多肽 >> 重组蛋白
重组核酸内切酶结构域蛋白1
产品介绍 基因名: ENDOD1 产品别名: ENDOD1; endonuclease domain containing 1; endonuclease domain containing 1; endonuclease domain-containing 1 protein; 核酸内切酶结构域蛋白1; 背景信息: ENDOD1 is a 500 amino acid secreted protein that belongs to the DNA/RNA non-specific endonuclease family. ENDOD1 is thought to act as a DNase and an RNase. The gene that encodes ENDOD1 maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. 标签:His-tag |
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